This study will consider the safety and effectiveness of a study drug, CAN04, in combination with pembrolizumab, in the treatment of incurable or metastatic non-small-cell lung cancer, head and neck squamous cell carcinoma, urothelial cancer, or malignant melanoma.

The results from the CANFOUR study for Cantargia's candidate CAN04 are imminent, due in Q4 2019 and early 2020. The outcome will, in our view, represent a major valuation trigger for the share and potentially also lead to a partnership deal.

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Can04

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The main project, the antibody CAN04, is being studied in the clinical phase I/IIa CANFOUR study with a primary focus on non-small cell lung cancer and pancreatic cancer. The study is focused on combination therapies, but also includes a monotherapy arm. Positive interim data from the combination therapies were presented in December 2019.

CAN04. Cantargia meddelar att första patienten inkluderats i fas IIa, en extensionsdel av CANFOUR-studien i bukspottkörtelcancer.

Denna studie kommer att beakta säkerheten och effektiviteten hos ett studieläkemedel, CAN04, i kombination med pembrolizumab, vid behandling av obotlig

Cantargia presenterade positiva effekter i prekliniska studier under 2018 kring CAN04 och cellgiftet cisplatin. 2021-04-01 · Cantargias läkemedelskandidat Can04 tillhör, liksom canakinumab, läkemedelsklassen IL-1. Starbreeze föll drygt 20 procent trots ett förlagsavtal med Embracerägda Koch Media för spelet Payday 3. Cantargia utvecklar antikroppsbaserade läkemedel mot interleukin-1 receptor accessory protein (IL1RAP). Antikroppen CAN04 binder IL1RAP med hög affinititet och fungerar både genom blockad av IL-1-signalering samt s.k.

Antikroppen CAN04 binder IL1RAP med hög affinititet och fungerar både genom blockad av IL-1-signalering samt s.k. Antibody-Dependent Cellular Cytotoxicity (ADCC). CAN04. Nulägesanalys av Cantargia – ett intressant case.
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Antibody-Dependent Cellular Cytotoxicity (ADCC). CAN04. Nulägesanalys av Cantargia – ett intressant case.

CAN04 undersöks i två kliniska studier. 2019-06-02 · CAN04 is a humanized and antibody-dependent cellular cytotoxicity (ADCC)-enhanced IgG1 antibody targeting IL1RAP with two modes of action: blocking IL-1 alpha and beta signaling and triggering ADCC. This study included 22 patients with non–small cell lung cancer (NSCLC; four patients), pancreatic ductal adenocarcinoma (six patients), or colorectal cancer (12 patients).
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A second ongoing trial investigates CAN04 in combination with two different chemotherapy regimens. The first patient has now been dosed with CAN04 in combination with pembrolizumab, the latter a

The antibody CAN04 binds IL1RAP with high affinity and functions through both Antibody-Dependent Cellular Cytotoxicity (ADCC) and blockade of interleukin-1 (IL-1) signaling. CAN04 increased the anti-tumor effects in mice when combined with different registered platinum-based therapies (cisplatin, carboplatin or oxaliplatin) in either a patient-derived NSCLC model or CAN04, an antibody targeting interleukin 1 receptor accessory protein (IL1RAP), is currently being investigated for treatment of non-small cell lung cancer (NSCLC) and pancreatic cancer (PDAC) in CAN04, an antibody targeting interleukin 1 receptor accessory protein (IL1RAP), is currently being investigated for treatment of non-small cell lung cancer (NSCLC) and pancreatic cancer (PDAC) in CAN04, an antibody targeting interleukin 1 receptor accessory protein (IL1RAP), is currently being investigated for treatment of non-small cell lung cancer (NSCLC) and pancreatic cancer (PDAC) in phase IIa clinical development in Europe. The main project, the antibody CAN04, is being studied in the clinical phase I/IIa CANFOUR study with a primary focus on non-small cell lung cancer and pancreatic cancer. The study is focused on combination therapies, but also includes a monotherapy arm. Positive interim data from the combination therapies were presented in December 2019.